The Substance Best Picture 2025. The substance ended up with five nominations in total: “the substance” (2024), directed by coralie fargeat, is a provocative body horror comedy that delves into the perils of vanity and the quest for eternal youth.

Conclave and wicked are leading this year’s lineup with 11 noms each, but who will nab the coveted best picture. The substance has just earned a best picture nomination at the 2025 oscars, and horror fans are taking to social media to express their enthusiasm.